First described in 1961, nonmetastatic hepatic dysfunction syndrome was first described in renal cell carcinoma and was called stauffer syndrome. Stauffer syndrome symptoms, diagnosis, treatments and. Although the company has come a long way from its beginnings in 1917, its dedication to creating strong communities has remained constant. Here, we describe a case of hepatic panel abnormalities in a patient with pancreatic cancer with no evidence of metastatic. It comes to you courtesy of the cleveland clinics disease management project dmp in collaboration with bulletin healthcare, the leading provider of medical news updates.
Maternal age incidence of down syndrome 20 1 in 2000 24 1 in 0 27 1 in 1050 30 1 in 900 33 1 in 600 36 1 in 300 40 1 in 100 42 1 in 70 45 1 in 30 47 1 in 20 48 1 in 15 49 1 in 10 5. Stauffers syndrome variant with cholestatic jaundice a case report. It is a syndrome of unclear pathophysiology characterized by a reversible anicteric elevation of liver enzymes, alkaline phosphatase. Maurice stauffer 19151994 was a gastroenterologist at the mayo clinic in rochester, united states, and in 1961 first characterised the nonmetastatic, paraneoplastic effects of renal cell carcinoma rcc on liver size and function 1. Stauffer syndrome is a rare paraneoplastic syndrome classically. Stauffer s syndrome corresponds to a set of clinical and analytical changes of paraneoplastic nature firstly recognized more than 50 years ago, in association to renal cell carcinoma. Stauffers syndrome variant with cholestatic jaundice. Stauffers syndrome as a prominent manifestation of renal. Renal cell carcinoma, stauffer syndrome, cholestasis. Ozlem yersal, samsun research and training hospital, baruthane. Pdf can i tell you about tourette syndrome download full. Prolongation of prothrombin time was not due to depletion of vitamin kdependent coagulation factors or manifest fibrinolysis. Digital signal processing 4th edition pdf by john g. Maurice stauffer, a gastroenterologist at the mayo clinic in rochester, mn.
Stauffer syndrome has been described in renal cell cancer patients. Includes free vocabulary trainer, verb tables and pronunciation function. Stauffer syndrome is a constellation of signs and symptoms of liver dysfunction that arises due to presence of renal cell carcinoma, and, more rarely, in connection with other malignant neoplasms, though the specific pathogenesis is currently unknown. Stauffer syndrome may precede other manifestations of renal cell carcinoma. T1 stauffers syndrome variant with cholestatic jaundice.
Ozlem yersal 1, nezih meydan 2, sabri barutca 2 1 samsun research and training hospital, turkey 2 department of oncology, adnan menderes university, turkey corresponding author. Ideal sources for wikipedia s health content are defined in the guideline wikipedia. Although nondisjunction can be of paternal origin, it is much less common. Stauffers syndrome variant with cholestatic jaundice a. Stickler syndrome basic information for patients and families stickler syndrome is a genetic disorder affecting collagen throughout the body. The mechanism of this apparent complication is unclear. Collagen is a primary part of connective tissue like bone, skin and cartilage. Stickler syndrome is a group of genetic disorders that a.
Stauffer syndrome stofer, elevation of liver function test results, in the absence of metastatic disease, due to cholestasis in renal cell cancer patients. Stauffers syndrome is a rare paraneoplastic manifestation of renal cell carcinoma rcc that is characterized by. It is a cause of cholestasis and cholestatic jaundice history and etymology. An unusual cause of painless jaundice gastroenterology. Stauffers syndrome corresponds to a set of clinical and analytical changes of paraneoplastic nature firstly recognized more than 50 years ago, in association to renal cell carcinoma. To report an sindrome paraneoplasico case of stauffers syndrome with jaundice as a paraneoplastic syndrome of a metastatic renal cancer. Cholestasis is a symptom that can be present in many conditions, such as bile duct obstruction by malignant mases, obstruction by gallstone, acute and chronic viral hepatitis, and autoimmune disorders, such as primary biliary and sclerosing cholangitis. Wcf insurance proves that doing the right thing is good. For more than 100 years, wcf insurance has been protecting both workers and employers as utahs premier workers compensation insurance provider. Rare manifestation of icteric variant of stauffers syndrome previous article 20. Stauffer s syndrome is a rare paraneoplastic manifestation of renal cell carcinoma rcc that is characterized by.
Stauffer syndrome a paraneoplastic condition characterised by biochemical changes. Stauffer syndrome is a rare paraneoplastic syndrome classically associated with renal cell carcinoma rcc. Case reports in radiology hindawi publishing corporation. Nonmetastatic hepatic dysfunction in patients suffering from renal cell carcinoma is known as stauffers syndrome. It presents as abnormal hepatic panel in the absence of. Initial investigations showed mildly elevated liver function tests lft, erythrocyte sedimentation rate. Developing a simple educational tool to improve resident and patient compliance with the screening and management of diabetic nephropathy. Amyloidosis and malabsorption syndrome jama internal. Interleukin 6 and other proinflammatory cytokines appear to contribute to. It is associated with the production of cytokines by the tumour, and several biochemical. As it may be the only manifestation of an otherwise occult rcc, its detection should prompt appropriate diagnostic efforts to enable an early diagnosis 12. Diagnosis with needle biopsy of liver in 18 patients, gastroenterology 41. Stauffer syndrome is a rare type of paraneoplastic syndrome that presents as cholestasis with absence of underlying disease.
The jaundice was associated with anorexia, a 15lb unintentional weight loss, pruritus, nausea, and acholic stools. Stauffers syndrome is a rare paraneoplastic syndrome classically associated with renal cell carcinoma. Stickler syndrome is also referred to as hereditary arthroophthalmodystro. Stauffers syndrome is a rare paraneoplastic manifestation of renal cell carcinoma rcc that is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate.
Renal cell carcinoma is associated with a wide spectrum of paraneoplastic syndromes, which may be precursors of primary or recurrent disease. Welcome to the latest edition of the cleveland clinic physicians guide to renal cell carcinoma rcc. Evaluation of renal function recovery in hemodialysis dependent patients next article 22. Spleen and liver problems associated with a kidney tumor. Marc stauffer, md is a cardiology specialist in tampa, fl and has been practicing for 14 years.
Stauffer s syndrome is a rare paraneoplastic manifestation of renal cell carcinoma rcc that is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate. Stauffers syndrome in patient with metastatic prostate cancer. Although the bacterial conjunctivitis may have been coincidental, spontaneous bilateral conjunctivitis caused by hemophilus influenzae is uncommon in adults. Furthermore, signs and symptoms of stauffer syndrome may vary on an individual basis for each patient. This means it can occur equally in males or females. A stauffers syndrome variant associated with renal cell carcinoma. Cases journal biomed central connecting repositories. Stauffers syndrome is a rare paraneoplastic manifestation of rcc that is characterized by elevated alkaline phosphatase alp, erythrocyte sedimentation rate. Stauffer s syndrome is a rare paraneoplastic syndrome classically associated with renal cell carcinoma. Kupffer cellderived tnf triggers cholangiocellular. This may allow early recognition and treatment of an occult malignancy. This association gave it the historical name of nonmetastatic nephrogenic hepatic dysfunction syndrome without jaundice. It is associated with the production of cytokines by the tumour, and several biochemical abnormalities, including elevated serum alkaline phosphatase.
This signs and symptoms information for stauffer syndrome has been gathered from various sources, may not be fully accurate, and may not be the full list of stauffer syndrome signs or stauffer syndrome symptoms. Stauffers syndrome is a rarely described paraneoplastic manifestation, which is described early in the course of rcc. Anicteric, intrahepatic cholestasis is the main form of stauffer s syndrome, while jaundice is uncommon 10,11. Pdf stauffers syndrome as a prominent manifestation of renal. We use cookies to enhance your experience on our website. Stauffer syndromedependent a giant renal tumor electronic. He specializes in cardiology and interventional cardiology. Paraneoplastic jaundice and prostate cancer bmj case reports. Look up the english to french translation of stauffer syndrome in the pons online dictionary.
There are only 11 articles published of patients with jaundice due to a paraneoplastic syndrome associated with prostate cancer. Stauffers syndrome is a rare paraneoplastic manifestation of renal cell carcinoma which is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate. Proakis, dimitris k manolakis a significant revision of a buy digital signal processing, 4e free shipping on and applications is a computer textbook written by dimitris g manolakis and john g. A 79yearold man with type 2 diabetes mellitus, hypertension, dyslipidemia, and benign prostatic hyperplasia presented to our institution with a 2 to 3week history of progressively worsening painless jaundice.
In 40 patients with nonmetastasising n31 and metastasising n9 renal cell carcinoma, evidence of stauffers syndrome increase in alkaline serum phosphatase and prolongation of prothrombin time was found in 18 patients. More detailed information about the symptoms, causes, and treatments of stauffer syndrome is available below symptoms of stauffer syndrome. A boy named max describes what life with tourette syndrome is like, explains what tics and triggers are, and suggests ways for parents and educators to help those who suffer from. Stauffer s syndrome is a rare paraneoplastic manifestation of renal cell carcinoma which is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate. We present the case of a 78yearold man with a common diagnosis in this age group and gender but with an unusual presentation. Stauffers syndrome is a rare paraneoplastic manifestation of renal cell. Sixty patients were included in this study and classified into one of four clinical syndromes to correlate the different types of quadriplegia to its final outcome. We believe that the nasal cpap apparatus caused bacterial conjunctivitis in our patient. The condition is characterized by facial abnormalities, ocular problems, hearing loss, and joint problems. What other names do people use for stickler syndrome. It most commonly occurs in the setting of renal cell carcinoma, and is the enlargement of the liver without hepatic metastases. Stauffers syndrome is a rare paraneoplastic manifestation of renal cell carcinoma which is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate, 2globulin, glutamyl transferase, thrombocytosis, prolongation of prothrombin time and hepatosplenomegaly, in the absence of hepatic metastasis and. Suspicion of rcc should prompt laboratory examinations of serum creatinine, haemoglobin, leukocyte and platelet counts. Incomplete quadriplegia following closed injuries to the cervical spine is studied for future prognosis of this increasingly common lesion.
Examination showed mild epigastric and left upper quadrant tenderness. Ozlem yersal, samsun research and training hospital, baruthane mahallesi, iskenderun sokak, no. Stauffer s syndrome as a prominent manifestation of renal cancer. We asked leading experts namita chittoria, md, and brian i. Rarely, in the absence of primary or metastatic liver disease, cholestasis can also be part of a paraneoplastic syndrome of certain malignant diseases. An international journal of medicine, volume 28, issue 1, 1 january 1959, pages 4358, s. Stauffers syndrome definition of stauffers syndrome by. N2 cholestasis is a common feature of several malignant diseases, including pancreatic, hepatic, gallbladder, and ampullary carcinomas. Stauffers syndrome in renal cell carcinoma evidence for. The trip database provides clinical publications about. Intrahepatic cholestasis without jaundice is the main findings that are commonly seen in stauffer syndrome 1. It is associated with the production of cytokines by the tumour, and several biochemical abnormalities, including elevated serum alkaline.
Anicteric, intrahepatic cholestasis is the main form of stauffers syndrome, while jaundice is uncommon 10,11. Stauffer syndrome is a constellation of signs and symptoms of liver dysfunction that arise due to presence of renal cell carcinoma but are not due to tumour inflitration into the liver andor intrinsic liver disease. Pdf stauffers syndrome as a prominent manifestation of. Stickler syndrome basic information for patients and families. We report a patient who presented with unresolving fever with multiple pulmonary opacities with biochemical evidence of hepatic. Biomed central page 1 of 4 page number not for citation purposes cases journal case report open access stauffers syndrome as a prominent manifestation of renal cancer. Nonmetastatic hepatic dysfunction in patients suffering from renal cell carcinoma is known as stauffer s syndrome. Prolonged pyrexia and weight loss are recognised paraneoplastic manifestations of renal cell carcinoma rcc. It presents as abnormal hepatic panel in the absence of hepatic disease, which improves with treatment of the cancer and worsens with recurrence. The rostnfjnk axis may be an effective target for intrahepatic cholangiocarcinoma therapy. Here, we describe a case of hepatic panel abnormalities in a patient with pancreatic cancer with no evidence of metastatic disease to the liver.
Stickler syndrome is an autosomal dominant genetic condition. The abnormalities stauffer described were renal cell carcinoma with. Some patients may be the first sign of the disease paraneoplastic. Based on the experience to date with central cord syndrome, most or all of the following conditions should be present before considering transurethral sphincterotomy. Stauffer syndrome is paraneoplastic nephrogenic hepatomegaly. Diagnosis of stauffers syndrome was confirmed based on his clinical history. It is named after maurice h stauffer, american gastroenterologist, working at the mayo clinic, who first. Stauffer syndrome is clinical diagnosis with unknown patho physiology. A stauffers syndrome variant associated with renal cell. Dear editor, stauffers syndrome we would like to report a case of stauffers syndrome.
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